Article
Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2008
Wang May-Yun, Grayburn Paul, Chen Shuyuan, Ravazzola Mariella, Orci Lelio, Unger Roger H
Abstract excerpt
To determine whether adipocyte storage capacity influences the onset and severity of type 2 diabetes and other components of the metabolic syndrome, we made normal and db/db mice resistant to obesity by overexpressing leptin receptor-b on the aP2-Lepr-b promoter. On a 4% diet, these mice have no phenotype, but on a 60% fat diet, they resist diet-induced obesity because constitutive adipocyte-specific...
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