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Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility.

Diabetes - 1 Mar 2003

Lan Hong, Rabaglia Mary E, Stoehr Jonathan P, Nadler Samuel T, Schueler Kathryn L, Zou Fei, Yandell Brian S, Attie Alan D

Abstract excerpt

Obesity is a strong risk factor for the development of type 2 diabetes. We have previously reported that in adipose tissue of obese (ob/ob) mice, the expression of adipogenic genes is decreased. When made genetically obese, the BTBR mouse strain is diabetes susceptible and the C57BL/6J (B6) strain is diabetes resistant. We used DNA microarrays and RT-PCR to compare the gene expression in BTBR-ob/ob versus...

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Identifiers

PMID: 12606510
DOI: 10.2337/diabetes.52.3.688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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