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Article

Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum.

Antimicrobial agents and chemotherapy - 1 Jun 2008

Mehlotra Rajeev K, Mattera Gabriel, Bockarie Moses J, Maguire Jason D, Baird J Kevin, Sharma Yagya D, Alifrangis Michael, Dorsey Grant, Rosenthal Philip J, Fryauff David J, Kazura James W, Stoneking Mark, Zimmerman Peter A

Abstract excerpt

Mutations in the chloroquine resistance (CQR) transporter gene of Plasmodium falciparum (Pfcrt; chromosome 7) play a key role in CQR, while mutations in the multidrug resistance gene (Pfmdr1; chromosome 5) play a significant role in the parasite's resistance to a variety of antimalarials and also modulate CQR. To compare patterns of genetic variation at Pfcrt and Pfmdr1 loci, we investigated 460 blood samples...

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Identifiers

PMID: 18411325
DOI: 10.1128/AAC.00089-08
PMCID: PMC2415780

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Source receipt: pubmed, retrieved 7 Sept 2026.

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