Article
Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon.
Memorias do Instituto Oswaldo Cruz - 1 Nov 2014
Lizcano Omaira Vera, Resende Sarah Stela, Chehuan Yonne F, Lacerda Marcus V G, Brito Cristiana F A, Zalis Mariano G
Abstract excerpt
The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our...
Topics
- Brazil
- Chloroquine
- DNA, Protozoan
- Drug Resistance
- Endemic Diseases
- Genetic Markers
- Genetic Variation
- Humans
- Malaria, Vivax
- Parasitic Sensitivity Tests
- Phenotype
- Plasmodium vivax
- Polymerase Chain Reaction
- Random Allocation