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Article

Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum.

Nature - 18 Jul 2002

Wootton John C, Feng Xiaorong, Ferdig Michael T, Cooper Roland A, Mu Jianbing, Baruch Dror I, Magill Alan J, Su Xin-Zhuan

Abstract excerpt

Widespread use of antimalarial agents can profoundly influence the evolution of the human malaria parasite Plasmodium falciparum. Recent selective sweeps for drug-resistant genotypes may have restricted the genetic diversity of this parasite, resembling effects attributed in current debates to a historic population bottleneck. Chloroquine-resistant (CQR) parasites were initially reported about 45 years ago from...

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PMID: 12124623
DOI: 10.1038/nature00813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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