Global-scale population genetic analysis of Plasmodium falciparum identifies region-specific patterns of malaria parasite adaptation.

doi:10.1038/s41467-026-73006-2

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Article

Global-scale population genetic analysis of Plasmodium falciparum identifies region-specific patterns of malaria parasite adaptation.

Nature communications - 11 May 2026

Billows Nina, Dombrowski Jamille G, Thorpe Joseph, Vanheer Leen, Moss Sophie, Gitaka Jesse, Sutherland Colin J, Marinho Claudio R F, Thi Hong Ngoc Nguyen, Thi Huong Binh Nguyen, Thieu Nguyen Quang, Campino Susana, Clark Taane G

Abstract excerpt

Malaria, caused by Plasmodium parasites, kills 610,000 people annually. The increasing availability of large-scale whole-genome sequencing (WGS) datasets enables investigation of parasite genetic diversity, population structure, and the spread of drug resistance. To investigate Plasmodium falciparum evolution, we analyse 17,565 isolates (17,489 previously published; 76 newly sequenced) from 39 countries, using...

Topics

Plasmodium falciparum
Drug Resistance
Malaria, Falciparum
Humans
Haplotypes
Genetic Variation
Genetics, Population
Genome, Protozoan
Whole Genome Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Artemisinins

Antimalarials

Selection, Genetic

Protozoan Proteins

Adaptation, Physiological

South America

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Identifiers

PMID: 42115185
DOI: 10.1038/s41467-026-73006-2
PMCID: PMC13377190

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