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Article

Evidence of functional interaction between NuMA-RARalpha and RXRalpha in an in vivo model of acute promyelocytic leukemia.

Oncogene - 7 Aug 2008

Sukhai M A, Thomas M, Xuan Y, Chan L S A, Hamadanizadeh S A, Zhang T, Bharadwaj R R, Schuh A C, Wells R A, Kamel-Reid S

Abstract excerpt

Acute promyelocytic leukemia (APL) is characterized by reciprocal balanced chromosomal translocations involving retinoic acid receptor-alpha (RARalpha). RARalpha heterodimerizes with the retinoid X receptor-alpha (RXRalpha) and transcriptionally regulates myeloid differentiation in response to ATRA (all-trans retinoic acid). Several lines of evidence suggest that APL fusion proteins interact with RXRalpha. To...

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Share to Leukemia, Promyelocytic, Acute
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Fusion

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Source

Identifiers

PMID: 18408763
DOI: 10.1038/onc.2008.106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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