Article
Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha.
Proceedings of the National Academy of Sciences of the United States of America - 25 May 1999
Cheng G X, Zhu X H, Men X Q, Wang L, Huang Q H, Jin X L, Xiong S M, Zhu J, Guo W M, Chen J Q, Xu S F, So E, Chan L C, Waxman S, Zelent A, Chen G Q, Dong S, Liu J X, Chen S J
Abstract excerpt
Acute promyelocytic leukemia (APL) is characterized by a specific chromosome translocation involving RARalpha and one of four fusion partners: PML, PLZF, NPM, and NuMA genes. To study the leukemogenic potential of the fusion genes in vivo, we generated transgenic mice with PLZF-RARalpha and NPM-RARalpha. PLZF-RARalpha transgenic animals developed chronic myeloid leukemia-like phenotypes at an early stage of life...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.