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Article

A <i>PMLRAR</i> α transgene initiates murine acute promyelocytic leukemia

18 Mar 1997

Abstract excerpt

The malignant cells of acute promyelocytic leukemia (APL) contain a reciprocal chromosomal translocation that fuses the promyelocytic leukemia gene (PML) with the retinoic acid receptor alpha gene (RAR alpha). To test the hypothesis that the chimera PMLRAR alpha plays a role in leukemogenesis, we expressed a PMLRAR alpha cDNA in myeloid cells of transgenic mice. PMLRAR alpha transgenic mice exhibited impaired...

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PMID: 9122233
DOI: 10.1073/pnas.94.6.2551

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A <i>PMLRAR</i> α transgene initiates murine acute promyelocytic leukemiaPMID 9122233Read ↗

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