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Acute leukemia with promyelocytic features in PML/RARα transgenic mice

13 May 1997

Abstract excerpt

Acute promyelocytic leukemia (APL) is associated with reciprocal chromosomal translocations involving the retinoic acid receptor alpha (RARalpha) locus on chromosome 17. In the majority of cases, RARalpha translocates and fuses with the promyelocytic leukemia (PML) gene located on chromosome 15. The resulting fusion genes encode the two structurally unique PML/RARalpha and RARalpha/PML fusion proteins as well as...

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PMID: 9144232
DOI: 10.1073/pnas.94.10.5302

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Acute leukemia with promyelocytic features in PML/RARα transgenic micePMID 9144232Read ↗

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