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Article

Transgenic expression of PML/RARalpha impairs myelopoiesis.

23 Jul 1996

Abstract excerpt

The translocation found in acute promyelocytic leukemia rearranges the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid receptor alpha (RARalpha) on chromosome 17. This yields a fusion transcript, PML/RARalpha, a transcription factor with reported dominant negative functions in the absence of hormone. Clinical remissions induced with all-trans retinoic acid (RA) treatment in acute...

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PMID: 8755574
DOI: 10.1073/pnas.93.15.7900

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