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Article

Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia.

Human molecular genetics - 1 Apr 2001

Pandolfi P P

Abstract excerpt

Acute promyelocytic leukemia (APL) is associated with reciprocal chromosomal translocations always involving the retinoic acid receptor alpha (RARalpha) gene on chromosome 17 and variable partner genes (X genes) on distinct chromosomes. RARalpha fuses to the PML gene in the vast majority of APL cases, and in a few cases to the PLZF, NPM, NuMA and Stat5b genes, respectively, leading to the generation of...

Read the complete abstract on PubMed

Topics

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Share to Cell Survival
Share to Chromosomes, Human, Pair 17
Share to Genes, Dominant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cells

Share to Leukemia, Promyelocytic, Acute

Share to Receptors, Retinoic Acid

Share to Retinoic Acid Receptor alpha

Share to Translocation, Genetic

Source

Identifiers

PMID: 11257111
DOI: 10.1093/hmg/10.7.769

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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