Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients.

Clinical pharmacology and therapeutics - 1 Oct 2006

Fukudo Masahide, Yano Ikuko, Masuda Satohiro, Goto Maki, Uesugi Miwa, Katsura Toshiya, Ogura Yasuhiro, Oike Fumitaka, Takada Yasutsugu, Egawa Hiroto, Uemoto Shinji, Inui Ken-ichi

Abstract excerpt

OBJECTIVE: Our objective was to investigate the population pharmacokinetics of tacrolimus in pediatric living-donor liver transplant recipients and examine the effects of the multidrug resistance 1 (MDR1) gene and the cytochrome P450 (CYP) genes CYP3A4 and CYP3A5 on the oral clearance of tacrolimus. METHODS: Data were collected retrospectively from 130 de novo pediatric liver transplant recipients treated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Genes, MDR

Share to Immunosuppressive Agents

Share to Liver Transplantation

Share to Living Donors

Share to Tacrolimus

Source

Identifiers

PMID: 17015051
DOI: 10.1016/j.clpt.2006.06.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients.PMID 17015051Read ↗

Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients.Semantic proximity Read ↗

Population pharmacokinetic and pharmacogenetic analysis of tacrolimus in paediatric liver transplant patients.Semantic proximity Read ↗

Influence of donor-recipient CYP3A4/5 genotypes, age and fluconazole on tacrolimus pharmacokinetics in pediatric liver transplantation: a population approach.Semantic proximity Read ↗

Population pharmacokinetics of tacrolimus and CYP3A5-driven variability: implications for model-informed dose individualization in pediatric renal transplant recipients.Semantic proximity Read ↗

Prediction of the tacrolimus population pharmacokinetic parameters according to CYP3A5 genotype and clinical factors using NONMEM in adult kidney transplant recipients.Semantic proximity Read ↗

GRWR Correlates with the Metabolism of Tacrolimus after Pediatric Living Donor Liver Transplantation According to Donor CYP3A5 Polymorphism.Semantic proximity Read ↗

Population pharmacokinetic models of tacrolimus in paediatric solid organ transplant recipients: A systematic review.Semantic proximity Read ↗

Population pharmacokinetics of tacrolimus and CYP3A5, MDR1 and IL-10 polymorphisms in adult liver transplant patients.Semantic proximity Read ↗

Population Pharmacokinetic Models of Tacrolimus in Adult Transplant Recipients: A Systematic Review.Semantic proximity Read ↗

Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation.Semantic proximity Read ↗

Population pharmacokinetic analyses of tacrolimus in non-transplant patients: a systematic review.Semantic proximity Read ↗

GRWR Correlates with the Metabolism of Tacrolimus After Pediatric Living Donor Liver Transplantation Accorrding to Donor CYP3A5 PolymorphismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.