Article
Effects of CYP3A4 and CYP3A5 polymorphisms on tacrolimus pharmacokinetics in Chinese adult renal transplant recipients: a population pharmacokinetic analysis.
Pharmacogenetics and genomics - 1 May 2013
Zuo Xiao-cong, Ng Chee M, Barrett Jeffrey S, Luo Ai-jing, Zhang Bi-kui, Deng Chen-hui, Xi Lan-yan, Cheng Ke, Ming Ying-zi, Yang Guo-ping, Pei Qi, Zhu Li-jun, Yuan Hong, Liao Hai-qiang, Ding Jun-jie, Wu Di, Zhou Ya-nan, Jing Ning-ning, Huang Zhi-jun
Abstract excerpt
OBJECTIVE: Tacrolimus is used clinically for the long-term treatment of antirejection of transplanted organs in liver and kidney transplant recipients, although dose optimization is poorly managed. The aim of this study was to examine the association between tacrolimus pharmacokinetic variability and CYP3A4 and CYP3A5 genotypes by a population pharmacokinetic analysis based on routine drug monitoring data in...
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