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Article

Local conservation scores without a priori assumptions on neutral substitution rates.

BMC bioinformatics - 11 Apr 2008

Dingel Janis, Hanus Pavol, Leonardi Niccolò, Hagenauer Joachim, Zech Jürgen, Mueller Jakob C

Abstract excerpt

BACKGROUND: Comparative genomics aims to detect signals of evolutionary conservation as an indicator of functional constraint. Surprisingly, results of the ENCODE project revealed that about half of the experimentally verified functional elements found in non-coding DNA were classified as unconstrained by computational predictions. Following this observation, it has been hypothesized that this may be partly...

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PMID: 18405366
DOI: 10.1186/1471-2105-9-190
PMCID: PMC2375903

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