Article

On estimating evolutionary probabilities of population variants

2018-11-21

Abstract excerpt

<h4>Background</h4> The evolutionary probability (EP) of an allele in a DNA or protein sequence predicts evolutionarily permissible (ePerm; EP ≥ 0.05) and forbidden (eForb; EP < 0.05) variants. EP of an allele represents an independent evolutionary expectation of observing an allele in a population based solely on the long-term substitution patterns captured in a multiple sequence alignment. In the neutral theory...

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Literature Corpus work: 3089ab67-602a-5df7-b62f-48bbb3eee84e
DOI: 10.1101/475475

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