Article
Quantitative estimates of sequence divergence for comparative analyses of mammalian genomes.
Genome research - 1 May 2003
Cooper Gregory M, Brudno Michael, Green Eric D, Batzoglou Serafim, Sidow Arend
Abstract excerpt
Comparative sequence analyses on a collection of carefully chosen mammalian genomes could facilitate identification of functional elements within the human genome and allow quantification of evolutionary constraint at the single nucleotide level. High-resolution quantification would be informative for determining the distribution of important positions within functional elements and for evaluating the relative...
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