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Article

Faster than neutral evolution of constrained sequences: the complex interplay of mutational biases and weak selection.

Genome biology and evolution - 1 Jan 2011

Lawrie David S, Petrov Dmitri A, Messer Philipp W

Abstract excerpt

Comparative genomics has become widely accepted as the major framework for the ascertainment of functionally important regions in genomes. The underlying paradigm of this approach is that most of the functional regions are assumed to be under selective constraint, which in turn reduces the rate of evolution relative to neutrality. This assumption allows detection of functional regions through sequence...

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Identifiers

PMID: 21498884
DOI: 10.1093/gbe/evr032
PMCID: PMC3101017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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