Article
Significant selective constraint at 4-fold degenerate sites in the avian genome and its consequence for detection of positive selection.
Genome biology and evolution - 1 Jan 2011
Künstner Axel, Nabholz Benoit, Ellegren Hans
Abstract excerpt
A major conclusion from comparative genomics is that many sequences that do not code for proteins are conserved beyond neutral expectations, indicating that they evolve under the influence of purifying selection and are likely to have functional roles. Due to the degeneracy of the genetic code, synonymous sites within protein-coding genes have previously been seen as "silent" with respect to function and thereby...
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