Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Divergence of conserved non-coding sequences: rate estimates and relative rate tests.

Molecular biology and evolution - 1 Nov 2004

Wagner Günter P, Fried Claudia, Prohaska Sonja J, Stadler Peter F

Abstract excerpt

In many eukaryotic genomes only a small fraction of the DNA codes for proteins, but the non-protein coding DNA harbors important genetic elements directing the development and the physiology of the organisms, like promoters, enhancers, insulators, and micro-RNA genes. The molecular evolution of these genetic elements is difficult to study because their functional significance is hard to deduce from sequence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cluster Analysis
Share to Conserved Sequence
Share to Fishes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome

Share to Models, Statistical

Share to Multigene Family

Share to Sharks

Share to Xenopus

Source

Identifiers

PMID: 15282332
DOI: 10.1093/molbev/msh221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Divergence of conserved non-coding sequences: rate estimates and relative rate tests.PMID 15282332Read ↗

Quantifying evolution and natural selection in vertebrate noncoding sequenceSemantic proximity Read ↗

Positive and negative selection in murine ultraconserved noncoding elements.Semantic proximity Read ↗

Primate deep conserved noncoding sequences and non-coding RNA: their possible relatedness to brain and Central Nervous SystemSemantic proximity Read ↗

No gene in the genome makes sense except in the light of evolution.Semantic proximity Read ↗

Fast-evolving noncoding sequences in the human genome.Semantic proximity Read ↗

Human variation in short regions predisposed to deep evolutionary conservation.Semantic proximity Read ↗

Evolutionary constraint and innovation across hundreds of placental mammalsSemantic proximity Read ↗

Distributions of selectively constrained sites and deleterious mutation rates in the hominid and murid genomes.Semantic proximity Read ↗

Nonsynonymous substitution rate (Ka) is a relatively consistent parameter for defining fast-evolving and slow-evolving protein-coding genes.Semantic proximity Read ↗

Local conservation scores without a priori assumptions on neutral substitution rates.Semantic proximity Read ↗

Evolutionary constraints in conserved nongenic sequences of mammals.Semantic proximity Read ↗

Genomic selective constraints in murid noncoding DNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.