Article
The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older persons.
Neuroepidemiology - 1 Jan 2010
Boyle Patricia A, Buchman Aron S, Wilson Robert S, Kelly Jeremiah F, Bennett David A
Abstract excerpt
BACKGROUND: The apolipoprotein E (APOE) epsilon4 allele is a well-known risk factor for the development of Alzheimer's disease, but little is known about the association of the epsilon4 allele with incident mild cognitive impairment (MCI). OBJECTIVE: Test the hypothesis that the epsilon4 allele i...
Topics
- Age Factors
- Aged
- Aged, 80 and over
- Apolipoprotein E4
- Cognition Disorders
- Disease Progression
- Educational Status
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Neuropsychological Tests
- Proportional Hazards Models
- Sex Factors
- Time Factors