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Article

Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension.

Journal of hypertension - 1 May 2008

Manunta Paolo, Maillard Marc, Tantardini Cristina, Simonini Marco, Lanzani Chiara, Citterio Lorena, Stella Paola, Casamassima Nunzia, Burnier Michel, Hamlyn John M, Bianchi Giuseppe

Abstract excerpt

OBJECTIVE: The basolateral Na pump drives renotubular reabsorption. In cultured renal cells, mutant adducins, as well as sub-nanomolar ouabain concentrations, stimulate the Na-K pump. METHODS: To determine whether these factors interact and affect Na handling and blood pressure (BP) in vivo, we studied 155 untreated hypertensive patients subdivided on the basis of their plasma endogenous ouabain or alpha-adducin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18398333
DOI: 10.1097/HJH.0b013e3282f5315f
PMCID: PMC3518487

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ADD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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