Adducin and hypertension.

doi:10.2217/14622416.6.7.665

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Article

Adducin and hypertension.

Pharmacogenomics - 1 Oct 2005

Staessen Jan A, Bianchi Giuseppe

Abstract excerpt

Adducin is a heterodimeric cytoskeleton protein consisting of an alpha-subunit and either a beta- or gamma-subunit. In rats and humans, mutation of the alpha-adducin subunit leads to the stimulation of the sodium (Na(+)), potassium (K(+))-adenosine triphosphate (ATP)-ase activity in renal tubular cells, increased renal Na(+) reabsorption, and, subsequently, hypertension. Ouabain is a hormone that is released by...

Topics

Alleles
Androstanols
Animals
Blood Pressure
Calmodulin-Binding Proteins
Forecasting
Heterozygote
Humans
Hypertension, Renal
Kidney Tubules
Mutation
Natriuresis
Ouabain
Polymorphism, Genetic
Protein Subunits
Rats
Sodium-Potassium-Exchanging ATPase

Source

Open in PubMed

Identifiers

PMID: 16207143
DOI: 10.2217/14622416.6.7.665

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