Article
Alpha-adducin and angiotensin-converting enzyme polymorphisms in hypertension: evidence for a joint influence on albuminuria.
Journal of hypertension - 1 May 2006
Pedrinelli Roberto, Dell'Omo Giulia, Penno Giuseppe, Di Bello Vitantonio, Pucci Laura, Fotino Carmen, Lucchesi Daniela, Del Prato Stefano, Dal Fiume Chiara, Barlassina Cristina, Cusi Daniele
Abstract excerpt
BACKGROUND: A single-nucleotide polymorphism (Gly460Trp) within the alpha-adducin gene (ADD1) may influence several renal phenotypes, including salt sensitivity, susceptibility to renal failure, the renal haemodynamics and confer a worse cardiovascular risks profile. However, its relationship with microalbuminuria, a marker of early renal and cardiovascular damage and an independent predictor of morbid events in...
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