Article
Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension.
Lancet (London, England) - 10 May 1997
Cusi D, Barlassina C, Azzani T, Casari G, Citterio L, Devoto M, Glorioso N, Lanzani C, Manunta P, Righetti M, Rivera R, Stella P, Troffa C, Zagato L, Bianchi G
Abstract excerpt
BACKGROUND: Abnormalities in renal sodium transport may be involved in hypertension. Adducin, an alpha/beta heterodimeric protein found in the renal tubule is thought to regulate ion transport through changes in the actin cytoskeleton. We investigated whether an alpha-adducin polymorphism (Gly 46...
Topics
- Aged
- Calmodulin-Binding Proteins
- Case-Control Studies
- Chromosome Mapping
- France
- Gene Frequency
- Genetic Carrier Screening
- Genetic Markers
- Humans
- Hypertension
- Middle Aged
- Mutation
- Polymorphism, Genetic
- Sodium Chloride, Dietary