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Article

Synergistic effect of alpha-adducin and ACE genes causes blood pressure changes with body sodium and volume expansion.

Kidney international - 1 Mar 2000

Barlassina C, Schork N J, Manunta P, Citterio L, Sciarrone M, Lanella G, Bianchi G, Cusi D

Abstract excerpt

BACKGROUND: The genetic dissection of a polygenic, multifactorial, quantitative disease such as arterial hypertension is hampered by a large environmental variance and by genetic heterogeneity. METHODS: To reduce the environmental variance, we measured the pressor response to a saline load (PRSL) and the basal plasma renin activity (PRA) under very controlled conditions in 145 essential hypertensive patients, as...

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Source

Identifiers

PMID: 10720960
DOI: 10.1046/j.1523-1755.2000.00935.x

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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