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Article

Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2008

Manunta Paolo, Lavery Gail, Lanzani Chiara, Braund Peter S, Simonini Marco, Bodycote Claire, Zagato Laura, Delli Carpini Simona, Tantardini Cristina, Brioni Elena, Bianchi Giuseppe, Samani Nilesh J

Abstract excerpt

The kidney plays an important role in salt and blood pressure (BP) homeostasis. In previous studies, variants in the genes for alpha-adducin (ADD1), WNK1, and NEDD4L, which all regulate renal sodium absorption, have been associated with increased BP. However, findings have been inconsistent. We tested whether this is because of physiological interactions between the effects of variants in these genes. We assessed...

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Source

Identifiers

PMID: 18591455
DOI: 10.1161/HYPERTENSIONAHA.108.113977

Genes

ADD1
WNK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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