Article
An observation that illustrates most T cell receptor structure-function relationships.
Immunologic research - 1 Dec 2017
Cohn Melvin
Abstract excerpt
The Standard model of the T cell receptor (TCR) structure-function relationships is based on an analogy with the B cell receptor. Here a single observation is analyzed to show why this appears to be untenable. The Standard model cannot account for allele-specific recognition of theMHC-encoded presenter of peptide (R) by the TCR nor can it adequately explain alloreactivity. The competing framework is based on the...
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