Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

What is the selective pressure that maintains the gene loci encoding the antigen receptors of T and B cells? A hypothesis.

Immunology and cell biology - 1 Dec 1992

Langman R E, Cohn M

Abstract excerpt

The dominant view is that the gene loci encoding the B cell antigen receptor (BAr) or the T cell antigen receptor (TAr) specify a vast array of combining sites. The 'germline' repertoire is estimated to be > 10(10) by multiplying numbers of subunit complements by DN-region variability. This implies that the germline can be maintained by a selection imposed by all or most of the antigenic universe. Its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Biological Evolution
Share to Genes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Ligands

Share to Models, Genetic

Share to Receptors, Antigen, T-Cell

Share to Selection, Genetic

Source

Identifiers

PMID: 1289241
DOI: 10.1038/icb.1992.52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

What is the selective pressure that maintains the gene loci encoding the antigen receptors of T and B cells? A hypothesis.PMID 1289241Read ↗

The evolutionary and structural 'logic' of antigen receptor diversity.Semantic proximity Read ↗

The evolution within usSemantic proximity Read ↗

Comparative Analysis of Mammalian Adaptive Immune Loci Revealed Spectacular Divergence and Common Genetic Patterns.Semantic proximity Read ↗

The Shape of the Lymphocyte Receptor Repertoire: Lessons from the B Cell ReceptorSemantic proximity Read ↗

Comparative analysis of mammalian adaptive immune loci revealed spectacular divergence and common genetic patternsSemantic proximity Read ↗

An observation that illustrates most T cell receptor structure-function relationships.Semantic proximity Read ↗

Germline-encoded specificities and the predictability of the B cell responseSemantic proximity Read ↗

Coevolution of T‐cell receptors with MHC and non‐ MHC ligandsSemantic proximity Read ↗

Chromatin topology and the regulation of antigen receptor assembly.Semantic proximity Read ↗

Receptor selection in B and T lymphocytes.Semantic proximity Read ↗

A B cell receptor variant confers evolutionary protection against pathogens.Semantic proximity Read ↗

Mechanisms of antigen receptor evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.