Article
Structurally interdependent and independent regions of allelic polymorphism in class II MHC molecules. Implications for Ia function and evolution.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1990
Braunstein N S, Germain R N, Loney K, Berkowitz N
Abstract excerpt
Possible interactions between regions of allelic polymorphism in the alpha- and beta-chains of class II MHC molecules were examined by measuring the efficiency of surface expression and the reactivity with mAb of wild-type and recombinant A alpha A beta-chain pairs from the b, d, and k haplotypes. These studies revealed regions of polymorphism within the alpha- and beta-chains that interact with complementary...
Topics
- Alleles
- Animals
- Antibodies, Monoclonal
- Epitopes
- Gene Expression
- Histocompatibility Antigens Class II
- L Cells
- Major Histocompatibility Complex
- Mice
- Models, Molecular
- Polymorphism, Genetic