Article
Rare TP53 genetic variant associated with glioma risk and outcome.
Journal of medical genetics - 1 Jul 2012
Egan Kathleen M, Nabors L Burton, Olson Jeffrey J, Monteiro Alvaro N, Browning James E, Madden Melissa H, Thompson Reid C
Abstract excerpt
Validation of a recent finding linking a rare variant in TP53 to the risk of glioma, the most common primary brain tumour, is reported here. This study genotyped the single nucleotide polymorphism (SNP) rs78378222 in 566 glioma cases and 603 controls. The variant 'C' allele (with an allelic frequency of 1.1% in controls) was associated with a 3.5-fold excess in glioma risk (odds ratio 3.54; p=0.0001). Variant...
Topics
- Alleles
- Case-Control Studies
- Gene Frequency
- Genetic Loci
- Genetic Predisposition to Disease
- Genotype
- Glioma
- Heterozygote