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Article

The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2008

Fava Cristiano, Montagnana Martina, Almgren Peter, Rosberg Lena, Lippi Giuseppe, Hedblad Bo, Engström Gunnar, Berglund Göran, Minuz Pietro, Melander Olle

Abstract excerpt

Cytochrome (CYP) 4A11 and CYP4F2 are responsible for renal production of 20-hydroxyeicosatetraenoic acid, a vasoconstrictor and natriuretic substance. The CYP4A11 F434S and CYP4F2 V433M polymorphisms reduce 20-hydroxyeicosatetraenoic acid production in vitro. The aim of the present study was to evaluate the effect of these polymorphisms on blood pressure (BP) levels, hypertension prevalence, and risk of incident...

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Identifiers

PMID: 18574070
DOI: 10.1161/HYPERTENSIONAHA.108.114199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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