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Article

Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension.

Pharmacogenetics and genomics - 1 Jan 2005

King Lorraine M, Gainer James V, David Gloria L, Dai Ding, Goldstein Joyce A, Brown Nancy J, Zeldin Darryl C

Abstract excerpt

CYP2J2 and CYP2C8 metabolize arachidonic acid (AA) to cis-epoxyeicosatrienoic acids (EETs), which play a central role in regulating renal tubular fluid-electrolyte transport and vascular tone. We hypothesized that functionally relevant polymorphisms in the CYP2J2 or CYP2C8 genes influence hypertension risk. We examined associations between CYP2J2*7 (G-50 T promoter) and CYP2C8*3 (Arg139Lys and Lys399Arg, which...

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Identifiers

PMID: 15864120
DOI: 10.1097/01213011-200501000-00002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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