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Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?

Prostaglandins & other lipid mediators - 1 Aug 2012

Fava Cristiano, Ricci Marco, Melander Olle, Minuz Pietro

Abstract excerpt

Hypertension is a multifactorial disease in which the interplay of genetic and environmental factors that maintain blood pressure stable throughout life is altered. Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been identified as...

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PMID: 22173545
DOI: 10.1016/j.prostaglandins.2011.11.007

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