Article
Profiling dendritic cell maturation with dedicated microarrays.
Journal of leukocyte biology - 1 Sept 2005
McIlroy Dorian, Tanguy-Royer Séverine, Le Meur Nolwenn, Guisle Isabelle, Royer Pierre-Joseph, Léger Jean, Meflah Khaled, Grégoire Marc
Abstract excerpt
Dendritic cell (DC) maturation is the process by which immature DC in the periphery differentiate into fully competent antigen-presenting cells that initiate the T cell response. However, DC respond to many distinct maturation stimuli, and different types of mature DC induce qualitatively different T cell responses. As DC maturation involves the coordinated regulation of hundreds of genes, comprehensive...
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