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Article

Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice.

Frontiers in immunology - 1 Jan 2018

Forteza Maria J, Polyzos Konstantinos A, Baumgartner Roland, Suur Bianca E, Mussbacher Marion, Johansson Daniel K, Hermansson Andreas, Hansson Göran K, Ketelhuth Daniel F J

Abstract excerpt

T-cell activation is characteristic during the development of atherosclerosis. While overall T-cell responses have been implicated in disease acceleration, regulatory T cells (Tregs) exhibit atheroprotective effects. The expression of the enzyme indoleamine 2,3-dioxygenase-1 (IDO1), which catalyzes the degradation of tryptophan (Trp) along the kynurenine pathway, has been implicated in the induction and expansion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29867939
DOI: 10.3389/fimmu.2018.00950
PMCID: PMC5949314

Genes

IDO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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