Article
Mutations of the PIK3CA gene in diffuse large B cell lymphoma.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Sept 2008
Baohua Yu, Xiaoyan Zhou, Tiecheng Zhang, Tao Qin, Daren Shi
Abstract excerpt
The PI3K/AKT pathway might be involved in the development of some certain diffuse large B-cell lymphoma (DLBCL) by as-yet unclear mechanisms. PIK3CA mutations in exons 9 and 20 were investigated in 76 primary human DLBCLs, 3 DLBCL cell lines (LY1, LY8, and LY10), and 9 related samples using polymerase chain reaction-based sequence analysis to assess the possible relevance of PIK3CA mutations in DLBCL to the...
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