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Article

Physiological levels of the PTEN-PI3K-AKT axis activity are required for maintenance of Burkitt lymphoma.

Leukemia - 1 Mar 2020

Gehringer Franziska, Weissinger Stephanie Ellen, Möller Peter, Wirth Thomas, Ushmorov Alexey

Abstract excerpt

In addition to oncogenic MYC translocations, Burkitt lymphoma (BL) depends on the germinal centre (GC) dark zone (DZ) B cell survival and proliferation programme, which is characterized by relatively low PI3K-AKT activity. Paradoxically, PI3K-AKT activation facilitates MYC-driven lymphomagenesis in mice, and it has been proposed that PI3K-AKT activation is essential for BL. Here we show that the PI3K-AKT activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31719683
DOI: 10.1038/s41375-019-0628-0
PMCID: PMC7214272

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