Article
Frequent copy number variations of PI3K/AKT pathway and aberrant protein expressions of PI3K subunits are associated with inferior survival in diffuse large B cell lymphoma.
Journal of translational medicine - 13 Jan 2014
Cui Wenli, Cai Ying, Wang Weige, Liu Zebing, Wei Ping, Bi Rui, Chen Weixiang, Sun Menghong, Zhou Xiaoyan
Abstract excerpt
BACKGROUND: It has been reported that the PI3K/AKT signaling pathway is activated in diffuse large B-cell lymphoma (DLBCL), PI3K constitutive activation plays a crucial role in PI3K/AKT pathway. However, the copy number variations (CNVs) of PI3K subunits on gene level remain unknown in DLBCL. Therefore, the aim of the study is to investigate the CNV of PI3K subunits and their relationship with clinicopathological...
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