Article
Constitutive AKT activation in follicular lymphoma.
BMC cancer - 5 Aug 2014
Yahiaoui Ouardia I, Nunès Jacques A, Castanier Céline, Devillier Raynier, Broussais Florence, Fabre Aurélie J, Naimi Dalila, Bouabdallah Réda, Olive Daniel, Xerri Luc
Abstract excerpt
BACKGROUND: The phosphoinositide 3- kinase (PI3K) pathway is involved in the growth of various human cancers, including lymphoid malignancies. However its role in the pathogenesis of follicular lymphoma (FL) has not been yet described. METHODS: To clarify this point, biopsy tissue samples from 38 human FL cases were investigated for PIK3CA somatic mutations in exon 9 and 20 using direct sequencing. The same...
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