Article
Frequent mutation of the PIK3CA gene in ovarian and breast cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2005
Levine Douglas A, Bogomolniy Faina, Yee Cindy J, Lash Alex, Barakat Richard R, Borgen Patrick I, Boyd Jeff
Abstract excerpt
PURPOSE: Activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway, resulting in increased cell proliferation, survival, and motility, is believed to play an oncogenic role in many cancer types. The PIK3CA gene encodes the p110alpha catalytic subunit of PI3K, and is amplified in some ovarian cancers, whereas the AKT2 gene is amplified in some ovarian, breast, and pancreatic cancers. Recently, in a...
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