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Article

Uncommon Mutation, but Common Amplifications, of the<i>PIK3CA</i>Gene in Thyroid Tumors

1 Aug 2005

Abstract excerpt

CONTEXT: As in many other human cancers, overactivation of the phosphotidylinositol 3-kinase (PI3K)/Akt signaling pathway occurs frequently in thyroid cancer, but the mechanism is not completely clear. OBJECTIVE: Because activating mutations and genomic amplification of the PIK3CA gene, which encodes the p110a catalytic subunit of PI3K, are common in many cancers, we sought to investigate this phenomenon in...

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Identifiers

PMID: 15928251
DOI: 10.1210/jc.2004-2281

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Uncommon Mutation, but Common Amplifications, of the<i>PIK3CA</i>Gene in Thyroid TumorsPMID 15928251Read ↗

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