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Article

Genetic variation in the one-carbon transfer pathway and ovarian cancer risk.

Cancer research - 1 Apr 2008

Kelemen Linda E, Sellers Thomas A, Schildkraut Joellen M, Cunningham Julie M, Vierkant Robert A, Pankratz V Shane, Fredericksen Zachary S, Gadre Madhura K, Rider David N, Liebow Mark, Goode Ellen L

Abstract excerpt

Dysfunction in enzymes involved in one-carbon (1-C) metabolism can lead to increased chromosomal strand breaking and abnormal methylation patterns, which are both associated with cancer risk. Availability of 1-C units may modify risk. We investigated the association of single-nucleotide polymorphisms (SNP) in 21 genes in the 1-C transfer pathway among 829 Caucasian cases with primary epithelial ovarian cancer and...

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Identifiers

PMID: 18381459
DOI: 10.1158/0008-5472.CAN-07-5165
PMCID: PMC2786310

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SHMT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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