Article
Single nucleotide polymorphisms in uracil-processing genes, intake of one-carbon nutrients and breast cancer risk.
European journal of clinical nutrition - 1 Jun 2011
Marian C, Tao M, Mason J B, Goerlitz D S, Nie J, Chanson A, Freudenheim J L, Shields P G
Abstract excerpt
BACKGROUND/OBJECTIVES: The misincorporation of uracil into DNA leads to genomic instability. In a previous study, some of us identified four common single nucleotide polymorphisms (SNPs) in uracil-processing genes (rs2029166 and rs7296239 in SMUG1, rs34259 in UNG and rs4775748 in DUT) that were associated with significantly altered levels of uracil in human DNA. We investigated whether any of these SNPs are...
Read the complete abstract on PubMed