Article
Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2010
Kelemen Linda E, Goodman Marc T, McGuire Valerie, Rossing Mary Anne, Webb Penelope M, Köbel Martin, Anton-Culver Hoda, Beesley Jonathan, Berchuck Andrew, Brar Sony, Carney Michael E, Chang-Claude Jenny, Chenevix-Trench Georgia, Cramer Daniel W, Cunningham Julie M, Dicioccio Richard A, Doherty Jennifer A, Easton Douglas F, Fredericksen Zachary S, Fridley Brooke L, Gates Margaret A, Gayther Simon A, Gentry-Maharaj Aleksandra, Høgdall Estrid, Kjaer Susanne Krüger, Lurie Galina, Menon Usha, Moorman Patricia G, Moysich Kirsten, Ness Roberta B, Palmieri Rachel T, Pearce Celeste L, Pharoah Paul D P, Ramus Susan J, Song Honglin, Stram Daniel O, Tworoger Shelley S, Van Den Berg David, Vierkant Robert A, Wang-Gohrke Shan, Whittemore Alice S, Wilkens Lynne R, Wu Anna H, Schildkraut Joellen M, Sellers Thomas A, Goode Ellen L
Abstract excerpt
BACKGROUND: We previously reported the risks of ovarian carcinoma for common polymorphisms in one-carbon transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS , and TYMS with risk of ovarian carcinoma overall and to u...