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Article

A Novel Lung Cancer Signature Mediates Metastatic Bone Colonization by a Dual Mechanism

1 Apr 2008

Abstract excerpt

Bone is a frequent target of lung cancer metastasis, which is associated with significant morbidity and a dismal prognosis. To identify and functionally characterize genes involved in the mechanisms of osseous metastasis, we developed a murine lung cancer model. Comparative transcriptomic analysis identified genes encoding signaling molecules (such as TCF4 and PRKD3) and cell anchorage-related proteins (MCAM and...

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PMID: 18381434
DOI: 10.1158/0008-5472.can-07-6493

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