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Exploiting bone niches: progression of disseminated tumor cells to metastasis

14 Mar 2021

Abstract excerpt

Many solid cancers metastasize to the bone and bone marrow (BM). This process may occur even before the diagnosis of primary tumors, as evidenced by the discovery of disseminated tumor cells (DTCs) in patients without occult malignancies. The cellular fates and metastatic progression of DTCs are determined by complicated interactions between cancer cells and BM niches. Not surprisingly, these niches also play...

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PMID: 33720051
DOI: 10.1172/jci143764

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