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Article

Connective tissue growth factor and its role in lung adenocarcinoma invasion and metastasis.

Journal of the National Cancer Institute - 3 Mar 2004

Chang Cheng-Chi, Shih Jin-Yuan, Jeng Yung-Ming, Su Jen-Liang, Lin Been-Zen, Chen Szu-Ta, Chau Yat-Pang, Yang Pan-Chyr, Kuo Min-Liang

Abstract excerpt

BACKGROUND: Tumor invasion and metastasis cause most deaths in cancer patients. Connective tissue growth factor (CTGF), a secreted protein that binds to integrins, modulates the invasive behavior of certain human cancer cells, but few mechanistic details are known. We investigated the roles of CTGF and collapsin response mediator protein 1 (CRMP-1) in metastasis and invasion of human lung adenocarcinoma. METHODS:...

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PMID: 14996858
DOI: 10.1093/jnci/djh059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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