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Article

Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors.

The Journal of clinical investigation - 1 Jan 2005

Minn Andy J, Kang Yibin, Serganova Inna, Gupta Gaorav P, Giri Dilip D, Doubrovin Mikhail, Ponomarev Vladimir, Gerald William L, Blasberg Ronald, Massagué Joan

Abstract excerpt

We used bioluminescence imaging to reveal patterns of metastasis formation by human breast cancer cells in immunodeficient mice. Individual cells from a population established in culture from the pleural effusion of a breast cancer patient showed distinct patterns of organ-specific metastasis. Single-cell progenies derived from this population exhibited markedly different abilities to metastasize to the bone,...

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Identifiers

PMID: 15630443
DOI: 10.1172/JCI22320
PMCID: PMC539194

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