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Article

A procedure for the detection of linkage with high density SNP arrays in a large pedigree with colorectal cancer.

BMC cancer - 12 Jan 2007

Middeldorp Anneke, Jagmohan-Changur Shantie, Helmer Quinta, van der Klift Heleen M, Tops Carli M J, Vasen Hans F A, Devilee Peter, Morreau Hans, Houwing-Duistermaat Jeanine J, Wijnen Juul T, van Wezel Tom

Abstract excerpt

BACKGROUND: The apparent dominant model of colorectal cancer (CRC) inheritance in several large families, without mutations in known CRC susceptibility genes, suggests the presence of so far unidentified genes with strong or moderate effect on the development of CRC. Linkage analysis could lead to identification of susceptibility genes in such families. In comparison to classical linkage analysis with...

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Identifiers

PMID: 17222328
DOI: 10.1186/1471-2407-7-6
PMCID: PMC1784097

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MLH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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